Impact of the growth hormone and IGF-1 on graft function and immune response in pediatric liver recipients

Growth hormone (GH) and insulin-like growth factor 1 (IGF-1) are the most important regulators of growth, regeneration metabolism. The influence GH IGF-1 on pediatric liver transplant outcomes is mediated through body weight regulation, specific effects hepatocyte function immune system activity. In recent years, blood levels these factors life expectancy, both in healthy individuals recipients, have been shown to be correlated. neurohumoral regulation graft other functions growing organism, has not studied enough. results studies dynamics recipients can serve as a basis for assessing state using new minimally invasive methods identifying therapeutic targets personalized therapy. This review summarizes current understanding significance GH/IGF-1 hormones hepatobiliary diseases transplantation (LTx).